Browsing by Subject "Solid tumors"
Now showing items 1-7 of 7
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Article
Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: A study of the EORTC early clinical studies group (ECSG)
(2000)Purpose: In a phase II trial, the activity of carzelesin, a cyclopropylpyrroloindole prodrug analog, was assessed. Patients and methods: Carzelesin was used as second- or third-line chemotherapy in patients with breast, ...
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Article
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
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Article
Endobronchial metastases secondary to solid tumors: Report of eight cases and review of the literature
(2000)Endobronchial metastases (EBM) secondaries to extrapulmonary solid malignant tumors are rare. Breast, colon and renal adenocarcinomas are the most frequent tumors associated with EBM. Since 1990 we have treated eight ...
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Conference Object
In vivo imaging of microvasculature using optical coherence tomography
(Correspondence Address: Vakoc, B. J., 2010)In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which ...
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Article
Multistage nanoparticles for improved delivery into tumor tissue
(2012)The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
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Article
Prevention of anemia in patients with solid tumors receiving platinum-based chemotherapy by recombinant human erythropoietin (rHuEPO): A prospective, open label, randomized trial by the hellenic cooperative oncology group
(2003)Objectives: Platinum compounds are commonly associated with significant anemia. Erythropoietin administration has been found effective in correcting anemia in patients with solid tumors receiving chemotherapy. We conducted ...
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Article
Solid Tumors Are Poroelastic Solids with a Chemo-mechanical Feedback on Growth
(2017)The experimental evidence that a feedback exists between growth and stress in tumors poses challenging questions. First, the rheological properties (the “constitutive equations”) of aggregates of malignant cells are still ...